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The focus is to develop enabling technologies that can have impact on techniques and technologies being employed to solve biological applications.
This group has two areas of interest:
Far field nanoscopy
An enduring question in nuclear architecture is the ‘transcription factory’ hypothesis. Do co-regulated genes relocated to ‘factories’ in the nucleus where they are co-transcribed?
Researchers aim to ‘engineer’ and build models of gene expression and regulation to enable single molecule detection of gene expression and seek answers to this question.
Gene expression and host pathogen interactions
The aim is to gain a deeper understanding of organisms at a systems level. Using high throughput biology researchers evaluate multiple biochemical and morphological parameters in cellular systems. The development of bio-imaging based assays is a central goal of this approach. Broad applications of single molecule imaging exist in molecular diagnostics and pharmacogenomics.The aim of this project is to enhance the study of synthetic biology by developing a single molecule imaging technology that will revolutionise the imaging of gene expression in vivo as well as develop advanced optical imaging approaches to achieve super resolution of biological objects. These studies will inform investigations into infectious disease and host pathogen induced transcription, screening of agents, drugs or small molecules that can ‘engineer’ transcription and to study stochasticity and ‘noise’ in gene expression.
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