Charles Maphanga


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Optical biosensing of mycobacterium tuberculosis biomarker for TB diagnosis

In this study, mycolic acid TB antigen is used as a biorecognition element immobilized on a biosensing surface of a gold-coated biosensor chip to bind antimycobacterium tuberculosis antibodies. To enhance the detection signal during optical detection using a custom-built nanoplasmonic setup, gold nanoparticles are bioconjugated to secondary antibody and introduced on the surface of the biosensor chip.