This presentation forms part of Teboho Mooko’s PhD study results. It addresses possible factors contributing to HIV-1 shedding into peritoneal dialysis effluent in end-stage kidney failure patients while on antiretroviral and renal replacement therapies. Furthermore, the innovative antiretroviral therapeutic stratagems in HIV control amongst patients on renal modality will be discussed. The research observations are intended to help improve current antiretroviral therapy dosing guidelines and clinical practices to prioritise high-risk patients, improve care and reduce treatment costs.