Vivey Phasha


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Formulation and Evaluation of Topical Application Products using fungal derivatives

The CSIR Advanced Agriculture and Food cluster, together with the University of KwaZulu-Natal through bioprospecting research, have identified an active ingredient from the cultures of Aspergillus Flavus that has potent tyrosinase inhibition activity, which was developed to address skin hyperpigmentation. Kojic Acid, an active ingredient, was produced via fungal fermentation, then modified to increase its stability, safety and efficacy.

The CSIR optimised the production of Kojic Acid and thereafter synthesised a stable derivative. The Kojic Acid and its derivative were assessed for safety and efficiency.  A serum formulation incorporating the derivative was then produced and evaluated for skin irritancy and stability. The results showed that it is stable and safe for use on humans.

This anti-pigmentation product technology has a competitive advantage over existing products on the market since it is safe for use and has scientific data proving its efficacy. This has a huge potential for application in the cosmetic industry.