Biomanufacturing

What we do

Contact information:

Dr Santosh Ramchuran
Research Group Leader: Bioprocess Technology Development
@email 

Ms Lara Kotzé-Jacobs
Programme Manager: Biomanufacturing Industrial Development Centre 
@email

Dr Dusty Gardiner
Impact Area Manager: Biomanufacturing
@email 

Dr Duduetsang Saku  
Business Development and Commercialisation Manager  
@email 

Highlights

Fungal protein for food security

Fungal protein for food security

The CSIR has developed a sustainable bioprocess to manufacture a fungal-based protein product for a South African biotechnology company called MycoSure. The starting material for the mycoprotein is Fusarium venenatum – a fungus known for its high protein content. CSIR researchers have developed a production process to make this protein in a bioreactor, offering several sustainability and cost advantages over livestock and crop-based protein production. This is the first time that this specific fungal protein production is applied in Africa. Watch.

Skills development for African vaccine manufacturing target

Skills development for African vaccine manufacturing target

The CSIR has trained 151 researchers and scientists from across Africa to help build African capacity for the manufacturing of biologics, vaccines, recombinant proteins and therapeutics. The training was part of the CSIR’s African Biomanufacturing Workforce Training and Skills Development Programme. Courses in biomanufacturing technologies, vaccine production and biopharmaceutical quality management systems were offered during 2023, 2024 and 2025. Watch.

CSIR develops protein for commercial fishing industry

CSIR develops protein for commercial fishing industry

The CSIR assisted Ziziba (Pty) Ltd, a small, medium and micro enterprise, with a scalable biobased technology to produce single-cell protein that is used as an ingredient in fish feed. The CSIR’s single-cell protein prototype is produced using a fungal-based biorefinery process that exploits industrial food waste streams as essential feedstocks during the synthesis of single-cell protein.

Our capabilities

 

We pioneer sustainable bio-based manufacturing by leveraging biological systems to create innovative, cost-effective technologies and products. With scalable infrastructure and deep technical expertise, we accelerate the journey from lab-scale discovery to commercial implementation, empowering industry with market-ready, environmentally responsible solutions.

person looking at chemicals

Our facilities
 

Bioprocessing facilities
Bioprocessing facilities

Our bioprocessing facilities offers technical support to small, medium and micro enterprises (SMMEs) who work in the development of biological products and speciality chemicals. During product and process development, the CSIR assists SMMEs with taking their ideas from the concept stage to market-ready products and supports them until pilot-scale production.

Microbial fermentation laboratory and pilot plant
Microbial fermentation laboratory and pilot plant

Our microbial fermentation laboratory and pilot plant are specialised facilities equipped with advanced bioreactors to cultivate living microbial cells to produce active pharmaceutical ingredients such as recombinant proteins or activated viruses. The lab supports scalable bioprocess development, from early-stage research to pilot-scale manufacturing, enabling the reliable translation of microbial innovations into high-quality biopharmaceutical products.

Mammalian cell culture laboratory
Mammalian cell culture laboratory

The mammalian cell culture laboratory is designed for the growth and maintenance of mammalian cell lines used in the production of complex biological compounds, including those essential for vaccine development. The facility features single-use and multi use bioreactors providing a sterile and flexible platform for cultivating sensitive cells under optimal conditions.

Microbiology laboratory
Microbiology laboratory

Our microbiology laboratory focuses on the isolation, screening and analysis of microbial cells, including bacteria, fungi and yeast, for a range of biotechnological applications. This controlled environment supports essential microbiological workflows such as the identification, characterisation and performance screening of microorganisms for research and industrial innovation.

Analytical laboratory
Analytical laboratory

Our analytical laboratory specialises in the precise analysis of compounds and bioprocesses, supporting quality control and the optimisation of product development. Equipped with high-performance liquid chromatography and gas chromatography systems, the lab enables accurate identification, quantification and profiling of chemical and biological substances.

Formulations laboratory
Formulations laboratory

The formulations laboratory focuses on transforming outputs from biological processes into final product prototypes. It supports the development, optimisation and testing of formulations to ensure stability, efficacy and usability. The lab plays a key role in bridging the gap between raw bio-based compounds and market-ready products.