African Cell Initiative™

African Cell Initiative™ 

Primary cellular models are becoming increasingly essential tools in preclinical drug discovery and development. However, those currently used in academic and pharmaceutical research pipelines fail to represent global genetic diversity, resulting in suboptimal treatment outcomes for a vast number of disparate population groups.

Contact information:

Dr Janine Scholefield
CSIR Research Group Leader: Bioengineering and integrated genomics
African Cell Initiative
@email

Dr Duduetsang Saku 
Business Development Manager
@email

 

 

Highlights

Stem cells

A sliver of brown skin for a world of new medicines

The CSIR has established iPSCs from Black African donors, creating a genetically diverse cellular resource – the African Cell Initiative™. These cells can become any cell type in the body, enabling disease research, drug screening, and access to Africa’s genomics for academic and commercial collaborations locally and internationally. Watch this video or read more about the African Cell Initiative™.

Transcriptomics and Genomics

Unlocking the potential of genome engineering in Africa

Watch this TEDx Talk to see how stem cell and genome engineering technologies are being used at the CSIR to create synthetic liver-like cells that reflect the unique genetic profiles of Africans. These innovative approaches are advancing precision medicine by enabling the development of safer and more effective treatments.

Capabilities 

 

genomics

Our expertise includes induced pluripotent stem cell (iPSC) reprogramming and genome engineering to develop preclinical solutions tailored to African populations and contexts. Furthermore, with the application of molecular biology and omics technologies we inform a deeper understanding of Africa’s unique genetic and biological landscape, enabling transformative insights into globally effective healthcare solutions.

Our facilities

genomics

Our work is supported by state-of-the-art laboratory infrastructure designed to accelerate translational research in precision medicine for African populations. This includes advanced stem cell culture and differentiation suites (including two Biosafety level-2 laboratories), and molecular biology laboratories equipped for multi-omics analysis.